MOTS-c — Autoimmune
Higher-dose immune-modulating protocol
Mitochondrial-derived peptide at an autoimmune-modulating dose.
Also sold as
Research chemical vendors can't legally label products with the real name, so MOTS-c — Autoimmune often appears under coded SKUs. If you're shopping and see any of these, it's the same compound:
- MOTS
- MOTS-C
Codes shown are for identification only.
Your draw
What it actually is
MOTS-c is encoded inside mitochondrial DNA and acts on AMPK to regulate metabolism and inflammation. At higher concentrations it appears to dampen aberrant immune signaling.
This is the higher-dose, higher-concentration version. MOTS-c Optimize uses the same peptide at roughly half the dose per injection in more BAC water for metabolic/energy goals.
Why people use it
- Hashimoto's, RA, MS, and other autoimmune patterns
- Chronic fatigue and post-viral syndromes
- Concentrated reconstitution (0.5 mL) keeps the dose volume small
Educational only · Not a vendor claim
Autoimmune vs Optimize
Same peptide, two different concentrations and dosing goals. Choose the column that matches your protocol.
- Goal
- Immune modulation
- Dose
- 5 mg
- BAC water
- 0.5 mL
- Concentration
- 20.0 mg/mL
- Units
- 25 units
- Frequency
- 3x per week
- Duration
- 8–12 weeks on, 8 weeks off
- Goal
- Metabolic optimization
- Dose
- 2.5 mg
- BAC water
- 2 mL
- Concentration
- 5.0 mg/mL
- Units
- 50 units
- Frequency
- 3x per week
- Duration
- 8 weeks on, 8 weeks off
Educational summary · Not medical advice · Discuss with a qualified clinician
How it works
Mitochondrial encoded peptide that activates AMPK. At the higher, more concentrated dose used here, the same mechanism appears to dampen aberrant immune signaling in addition to its metabolic effects.
Health benefits
- Immune-modulating action at higher per-dose concentrations
- Improved mitochondrial function
- Anti-inflammatory signaling
What you'll feel
- Reduced flare frequency
- Energy lift
- Better cold tolerance
Pros
- Targets root mitochondrial dysfunction
- Strong immune-modulating action when dosed higher
- Compact dose volume (0.5 mL reconstitution)
Cons
- Expensive at therapeutic doses
- Limited human trial data
- Effects gradual
Side effects to know
- Mild fatigue early on
- Rare GI upset
Best suited for
Educational summary · Not medical advice · Discuss with a qualified clinician
Typical timeline
General pattern for the Mitochondrial category. Individual response varies.
- Week 1Energy floor lifts. Fewer afternoon crashes. Workouts feel less taxing.
- Weeks 2–4Endurance and recovery both improve. Some users report better glucose control.
- Weeks 4–8Peak effect. Consider a break so mitochondrial adaptation is preserved, not blunted.
The reconstitution math
- 1Reconstitute the 10 mg vial with 0.5 mL of bacteriostatic water. Tilt — don't shake.
- 2Concentration becomes 20,000 mcg/mL (20 mg/mL).
- 3For a 5 mg dose, draw 0.250 mL — that's 25 units on a 1 mL insulin syringe.
- 4One vial gives you approximately 2 doses.
Reminder: 100 units on an insulin syringe = 1 mL. Always start at half the listed dose for the first week and rotate injection sites between arms, legs, abdomen, and glutes.
Dose logging is available for signed-in users. Track today's dose and notes for MOTS-c — Autoimmune.
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Mixing ratios, units to draw and storage basics — one page, no strings.
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Keep going from here
Everything on the site that connects to MOTS-c — Autoimmune: comparable compounds, the exact math for this vial, and the tools to run the cycle.
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Tools for this protocol
Prefilled with 10 mg, 0.5 mL BAC water, and a 5 mg dose.
Printable units-to-micrograms lookup for every common vial and water volume.
Add MOTS-c — Autoimmune to a protocol with schedule, dosing, and a shopping list.
Log each dose so you can tie effects and side effects to real dates.
Put MOTS-c — Autoimmune next to two other peptides on dosing and goals.
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