MOTS-c — Autoimmune
Mitochondrial function
Mitochondrial derived peptide at autoimmune modulating dose.
Research chemical vendors can't legally label products with the real name, so MOTS-c — Autoimmune often appears under coded SKUs. If you're shopping and see any of these, it's the same compound:
- MOTS
- MOTS-C
Codes shown are for identification only. Always verify third-party COAs before purchase.
MOTS-c is encoded inside mitochondrial DNA and acts on AMPK to regulate metabolism and inflammation. At higher concentrations it appears to dampen aberrant immune signaling.
- Hashimoto's, RA, MS, and other autoimmune patterns
- Chronic fatigue and post viral syndromes
- Concentrated reconstitution (0.5 mL) keeps the dose volume small
Educational only · Not a vendor claim
Mitochondrial encoded peptide that activates AMPK and dampens aberrant immune signaling at higher doses.
- Modulates autoimmune flares
- Improves mitochondrial function
- Anti inflammatory
- Reduced flare frequency
- Energy lift
- Better cold tolerance
- Targets root mitochondrial dysfunction
- Strong autoimmune modulating action
- Compact dose volume
- Expensive at therapeutic doses
- Limited human trial data
- Effects gradual
- Mild fatigue early on
- Rare GI upset
Educational summary · Not medical advice · Discuss with a qualified clinician
Typical timeline
General pattern for the Mitochondrial category. Individual response varies.
- Week 1Energy floor lifts. Fewer afternoon crashes. Workouts feel less taxing.
- Weeks 2–4Endurance and recovery both improve. Some users report better glucose control.
- Weeks 4–8Peak effect. Consider a break so mitochondrial adaptation is preserved, not blunted.
The reconstitution math
- 1Reconstitute the 10 mg vial with 0.5 mL of bacteriostatic water. Tilt — don't shake.
- 2Concentration becomes 20,000 mcg/mL (20 mg/mL).
- 3For a 5 mg dose, draw 0.250 mL — that's 25 units on a 1 mL insulin syringe.
- 4One vial gives you approximately 2 doses.
Reminder: 100 units on an insulin syringe = 1 mL. Always start at half the listed dose for the first week and rotate injection sites between arms, legs, abdomen, and glutes.
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