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Muscle

Sermorelin dosing guide

The original GHRH analog — gentle, well studied, FDA history.. Everything below is the arithmetic of this vial — what to mix, what to draw, how often, and for how long.

Also sold as: sermo, grf 1-29

The protocol at a glance

Vial size
10 mg
Bacteriostatic water
2 mL
Concentration
5.00 mg/mL
Dose
375 mcg
Draw on a 1 mL syringe
8 units
Timing
PM
Frequency
Daily
Cycle length
12–16 weeks on
Doses per vial
about 26
Draw to here
00.0100.1200.2300.3400.4500.5600.6700.7800.8900.91001.0DRAW TO 8u100-UNIT · 1 mL SYRINGESermorelin
Change the vial or water volume in the calculator →

Mixing it, step by step

Step by step

Reconstitution steps

Every step below uses the numbers you entered above.

  1. 1
    Wipe both stoppers

    Swab the rubber tops of the 10 mg Sermorelin vial and the bacteriostatic water vial with fresh alcohol pads. Let them air dry for a few seconds.

  2. 2
    Draw 2 mL of BAC water

    Pull 2 mL of bacteriostatic water into a reconstitution syringe (usually a 3 mL syringe with a 21g needle).

  3. 3
    Add water slowly, down the side

    Inject the water against the inside wall of the vial, don't blast it directly onto the powder. This protects the peptide from shear damage.

  4. 4
    Swirl, don't shake

    Gently swirl until the powder is fully dissolved and the liquid is clear. Never shake, foaming denatures the peptide.

  5. 5
    Draw 8 units on a 1 mL syringe

    On your 100-unit (1 mL) insulin syringe, pull the plunger back until the rubber tip lines up with 8, that's your 375 mcg dose. Tap out any air bubbles, then inject as directed.

  6. 6
    Store refrigerated

    Cap the vial and store at 2–8 °C (36–46 °F). Most reconstituted peptides remain stable for 3–4 weeks refrigerated.

What to expect, week by week

Week 1

Deeper sleep, vivid dreams, possible morning hand tingling — normal GH-axis signals.

Weeks 2–4

Recovery between sessions improves. Modest fullness in muscles from mild water retention.

Weeks 4–8

Body comp changes become visible. Fat drops slightly, muscle looks fuller. Bloodwork check recommended.

Weeks 8+

Cycle off for at least equal time to restore natural pulsatility. Track IGF-1 if running longer.

Side effects to watch

  • Injection site redness
  • Mild headache
  • Rare flushing

Why people run it

  • Restored GH/IGF-1 in aging adults
  • Better sleep depth
  • Subtle body composition improvement

What to stack it with

Ready to run Sermorelin?

Read the full compound page, or check current pricing.

Educational reference only. Doses shown reflect commonly reported research protocols and are not medical advice.

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