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Muscle

MK-677 (Ibutamoren) dosing guide

An oral GH secretagogue, so no needles and no reconstitution.. Everything below is the arithmetic of this vial — what to mix, what to draw, how often, and for how long.

Also sold as: mk677, mk 677, ibutamoren, mk-0677, nutrobal

The protocol at a glance

Vial size
25 mg
Bacteriostatic water
1 mL
Concentration
25.00 mg/mL
Dose
15 mg
Draw on a 1 mL syringe
0 units
Timing
PM
Frequency
Every day
Cycle length
8–12 weeks on, 4 off
Doses per vial
about 1

Oral capsule/liquid — no injection. Standard dose: 10–25mg/day; most start at 15mg and adjust for water retention & appetite.

Draw to here
00.0100.1200.2300.3400.4500.5600.6700.7800.8900.91001.0100-UNIT · 1 mL SYRINGEMK-677 (Ibutamoren)
Change the vial or water volume in the calculator →

Mixing it, step by step

Step by step

Reconstitution steps

Every step below uses the numbers you entered above.

  1. 1
    Wipe both stoppers

    Swab the rubber tops of the 25 mg MK-677 (Ibutamoren) vial and the bacteriostatic water vial with fresh alcohol pads. Let them air dry for a few seconds.

  2. 2
    Draw 1 mL of BAC water

    Pull 1 mL of bacteriostatic water into a reconstitution syringe (usually a 3 mL syringe with a 21g needle).

  3. 3
    Add water slowly, down the side

    Inject the water against the inside wall of the vial, don't blast it directly onto the powder. This protects the peptide from shear damage.

  4. 4
    Swirl, don't shake

    Gently swirl until the powder is fully dissolved and the liquid is clear. Never shake, foaming denatures the peptide.

  5. 5
    Draw 0 units on a 1 mL syringe

    On your 100-unit (1 mL) insulin syringe, pull the plunger back until the rubber tip lines up with 0, that's your 15.00 mg dose. Tap out any air bubbles, then inject as directed.

  6. 6
    Store refrigerated

    Cap the vial and store at 2–8 °C (36–46 °F). Most reconstituted peptides remain stable for 3–4 weeks refrigerated.

What to expect, week by week

Week 1

Deeper sleep, vivid dreams, possible morning hand tingling — normal GH-axis signals.

Weeks 2–4

Recovery between sessions improves. Modest fullness in muscles from mild water retention.

Weeks 4–8

Body comp changes become visible. Fat drops slightly, muscle looks fuller. Bloodwork check recommended.

Weeks 8+

Cycle off for at least equal time to restore natural pulsatility. Track IGF-1 if running longer.

Side effects to watch

  • Water retention
  • Morning lethargy
  • Numb or tingling hands
  • Raised fasting glucose

Why people run it

  • Sustained IGF-1 elevation
  • Deep sleep
  • Appetite and lean mass support
  • No injections

Ready to run MK-677 (Ibutamoren)?

Read the full compound page, or check current pricing.

Educational reference only. Doses shown reflect commonly reported research protocols and are not medical advice.

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