MK-677 (Ibutamoren)
Oral GH secretagogue
An oral GH secretagogue, so no needles and no reconstitution.
Also sold as
Research chemical vendors can't legally label products with the real name, so MK-677 (Ibutamoren) often appears under coded SKUs. If you're shopping and see any of these, it's the same compound:
- MK677
- Ibutamoren
- MK-0677
- Nutrobal
Codes shown are for identification only.
Your draw
What it actually is
MK-677 (ibutamoren) is a non-peptide ghrelin receptor agonist taken by mouth. It raises GH and IGF-1 for roughly 24 hours per dose, which is why it is dosed nightly rather than pulsed like injectable secretagogues.
10 to 25mg nightly, most start at 15mg. Expect water retention and hunger. Check fasting glucose and A1c: MK-677 can reduce insulin sensitivity.
Why people use it
- Sustained IGF-1 elevation without injections
- Deeper sleep and faster recovery
- Appetite and lean mass support during a bulk
Educational only · Not a vendor claim
How it works
Oral non-peptide ghrelin receptor agonist that keeps GH and IGF-1 elevated for about 24 hours per dose.
Health benefits
- Sustained IGF-1 elevation
- Deep sleep
- Appetite and lean mass support
- No injections
What you'll feel
- Vivid dreams and heavy sleep in week 1
- Noticeable hunger
- Water weight in the first 2 weeks
Pros
- Oral convenience
- Once-daily dosing
- Strong, measurable IGF-1 response
Cons
- Water retention and puffiness
- Reduces insulin sensitivity
- Hunger is hard to manage on a cut
Side effects to know
- Water retention
- Morning lethargy
- Numb or tingling hands
- Raised fasting glucose
Best suited for
Educational summary · Not medical advice · Discuss with a qualified clinician
Typical timeline
General pattern for the Muscle category. Individual response varies.
- Week 1Deeper sleep, vivid dreams, possible morning hand tingling — normal GH-axis signals.
- Weeks 2–4Recovery between sessions improves. Modest fullness in muscles from mild water retention.
- Weeks 4–8Body comp changes become visible. Fat drops slightly, muscle looks fuller. Bloodwork check recommended.
- Weeks 8+Cycle off for at least equal time to restore natural pulsatility. Track IGF-1 if running longer.
The reconstitution math
- 1Reconstitute the 25 mg vial with 1 mL of bacteriostatic water. Tilt — don't shake.
- 2Concentration becomes 25,000 mcg/mL (25 mg/mL).
- 3For a 15 mg dose, draw 0.600 mL — that's 0 units on a 1 mL insulin syringe.
- 4One vial gives you approximately 1 doses.
Reminder: 100 units on an insulin syringe = 1 mL. Always start at half the listed dose for the first week and rotate injection sites between arms, legs, abdomen, and glutes.
Dose logging is available for signed-in users. Track today's dose and notes for MK-677 (Ibutamoren).
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Keep going from here
Everything on the site that connects to MK-677 (Ibutamoren): comparable compounds, the exact math for this vial, and the tools to run the cycle.
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Tools for this protocol
Prefilled with 25 mg, 1 mL BAC water, and a 15 mg dose.
Printable units-to-micrograms lookup for every common vial and water volume.
Add MK-677 (Ibutamoren) to a protocol with schedule, dosing, and a shopping list.
Log each dose so you can tie effects and side effects to real dates.
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