Tirzepatide is a once weekly GLP-1 and GIP agonist. Enter your vial size, the water you add and your weekly dose, and the syringe shows exactly how many units to draw.
= 2,500 mcg | Weekly dose. Most protocols start at 2.5 mg.
1 mg = 1,000 mcg (micrograms). Most peptide protocols are written in mcg.
Common vial sizes are 5, 10, 15, 20 and 30 mg.
For a 10 mg vial mixed with 2 mL bacteriostatic water (5.00 mg/mL), on a U-100 insulin syringe.
| Dose | Volume | Units | Doses per vial |
|---|---|---|---|
| 1 mg | 0.200 mL | 20u | 10 |
| 2.5 mg | 0.500 mL | 50u | 4 |
| 5 mg | 1.000 mL | 100u | 2 |
| 7.5 mg | 1.500 mL | 150u | 1 |
| 10 mg | 2.000 mL | 200u | 1 |
| 12.5 mg | 2.500 mL | 250u | 0 |
| 15 mg | 3.000 mL | 300u | 0 |
Units shown for your current vial and water amount (10 mg / 2 mL).
| Weeks | Weekly dose | Units to draw |
|---|---|---|
| 1 to 4 | 2.5 mg | 50u |
| 5 to 8 | 5 mg | 100u |
| 9 to 12 | 7.5 mg | 150u |
| 13 to 16 | 10 mg | 200u |
| 17 to 20 | 12.5 mg | 250u |
| 21+ | 15 mg | 300u |
Based on clinical trial titration. Only move up when the current dose is well tolerated.
Tirzepatide is injected once a week on the same day, under the skin of the abdomen, thigh or upper arm. Clinical titration starts at 2.5 mg and steps up by 2.5 mg every 4 weeks only as tolerated, to a maximum of 15 mg.
Mix gently by swirling, never shake, and keep the reconstituted vial in the fridge. If nausea is strong, stay at your current dose longer before stepping up.
Every step below uses the numbers you entered above.
Swab the rubber tops of the 10 mg Tirzepatide vial and the bacteriostatic water vial with fresh alcohol pads. Let them air dry for a few seconds.
Pull 2 mL of bacteriostatic water into a reconstitution syringe (usually a 3 mL syringe with a 21g needle).
Inject the water against the inside wall of the vial, don't blast it directly onto the powder. This protects the peptide from shear damage.
Gently swirl until the powder is fully dissolved and the liquid is clear. Never shake, foaming denatures the peptide.
On your 100-unit (1 mL) insulin syringe, pull the plunger back until the rubber tip lines up with 50, that's your 2.50 mg dose. Tap out any air bubbles, then inject as directed.
Cap the vial and store at 2–8 °C (36–46 °F). Most reconstituted peptides remain stable for 3–4 weeks refrigerated.
With a 10 mg vial mixed with 2 mL of bacteriostatic water (5 mg/mL), 2.5 mg is 0.5 mL, which is 50 units on a U-100 insulin syringe.
Most people add 1 to 2 mL. 2 mL gives 5 mg/mL, so every 10 units equals 1 mg, which makes the math easy.
Start at 2.5 mg weekly for 4 weeks, then increase by 2.5 mg every 4 weeks as tolerated: 5, 7.5, 10, 12.5 and up to 15 mg.
Once a week, on the same day each week, at any time of day, with or without food.
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Educational only. Not medical advice.
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