FOXO4-DRI
Senolytic
Senolytic peptide — for clearing zombie cells that drive aging.
Research chemical vendors can't legally label products with the real name, so FOXO4-DRI often appears under coded SKUs. If you're shopping and see any of these, it's the same compound:
- FOXO4
- Senolytic Peptide
Codes shown are for identification only. Always verify third-party COAs before purchase.
FOXO4-DRI disrupts the FOXO4-p53 interaction that keeps senescent ('zombie') cells alive. With that interaction broken, those cells undergo apoptosis while healthy cells are spared.
- Reducing senescent cell burden, which rises with age and drives inflammation
- Short, intense protocols (two weeks, two or three times a year)
- Frequently reported subjective improvements in skin, hair, and energy after a cycle
Educational only · Not a vendor claim
Disrupts the FOXO4-p53 complex inside senescent cells, triggering their apoptosis while sparing healthy cells.
- Clears senescent ('zombie') cells
- Lowers inflammaging
- Reported skin/hair improvements
- Subjective energy lift post cycle
- Skin tone improvement
- Hair density changes (anecdotal)
- Targeted senolytic mechanism
- Short, infrequent cycles
- Strong animal data
- Limited human evidence
- Expensive
- Aggressive mechanism — quality matters
- Flu like symptoms during cycle
- Fatigue
- Mild inflammation rebound
Educational summary · Not medical advice · Discuss with a qualified clinician
Typical timeline
General pattern for the Longevity category. Individual response varies.
- Week 1Usually no acute feel. Sleep may deepen. Some report clearer thinking within days.
- Weeks 2–3Subjective energy and skin quality often improve. Effects are cumulative, not dramatic.
- Post-cycleBenefits persist for months. Repeat cycles 2–3 times per year is the common cadence.
The reconstitution math
- 1Reconstitute the 10 mg vial with 2 mL of bacteriostatic water. Tilt — don't shake.
- 2Concentration becomes 5,000 mcg/mL (5 mg/mL).
- 3For a 1 mg dose, draw 0.200 mL — that's 20 units on a 1 mL insulin syringe.
- 4One vial gives you approximately 10 doses.
Reminder: 100 units on an insulin syringe = 1 mL. Always start at half the listed dose for the first week and rotate injection sites between arms, legs, abdomen, and glutes.
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