Fat Loss

CagriSema Blend

GLP-1 + amylin fat loss blend (Cagrilintide / Semaglutide)

GLP-1 plus amylin — the pairing behind the strongest fat loss data of the decade.

Vial

10 mg

BAC Water

2 mL

Dose

500 mcg

Units on 1 mL

Timing

Frequency

1x per week

Duration

Until goal weight

Note: Per dose: 250mcg Cagrilintide / 250mcg Semaglutide

Also sold as

Research chemical vendors can't legally label products with the real name, so CagriSema Blend often appears under coded SKUs. If you're shopping and see any of these, it's the same compound:

CagriSema
Sema+Cagri
1S + Cagri

Codes shown are for identification only.

Your draw

10 units · 500 mcg

On a standard 100-unit / 1 mL insulin syringe.

What it actually is

CagriSema pairs Semaglutide (a GLP-1 receptor agonist) with Cagrilintide (a long acting amylin analog). Amylin hits satiety pathways GLP-1 misses, which is why in trials this combo produced meaningfully greater weight loss than either alone — with less appetite rebound between doses.

Titrate up slowly — combined GI side effects can be additive in the first 2–3 weeks.

Why people use it

Better weekly appetite control than semaglutide alone
Smoother glucose curves through the week
Less 'food noise' and evening hunger
Stalled semaglutide users looking for a next step

Educational only · Not a vendor claim

How it works

Semaglutide activates GLP-1 receptors (satiety, gastric emptying, insulin). Cagrilintide is a long acting amylin analog that hits satiety and glucose control through a separate pathway. Together they cover appetite regulation more completely than either alone.

Health benefits

Greater weekly weight loss than semaglutide alone
Reduced 'food noise' between doses
Smoother glucose curves
Better lean mass preservation vs. sema monotherapy

What you'll feel

Appetite drop within days
Steadier energy through the week
Weight loss of 15–25%+ in trial data over 68 weeks

Pros

Strongest published fat loss data of any current stack
Weekly dosing
Better tolerability than dose maxed semaglutide

Cons

GI side effects can stack in the first weeks
More expensive than semaglutide alone
Requires slow titration

Side effects to know

Nausea, constipation, or diarrhea (usually transient)
Fatigue
Reduced appetite for muscle building nutrition

Best suited for

Stalled semaglutide usersUsers chasing >15% body weight lossMetabolic syndrome recompPrediabetics needing stronger glucose control

Educational summary · Not medical advice · Discuss with a qualified clinician

What to expect

Typical timeline

General pattern for the Fat Loss category. Individual response varies.

Week 1
Titrate up slowly. Expect appetite drop, mild nausea, and possible constipation with GLP-1s. Hydrate and lean on fiber.
Weeks 2–4
Steady weight trend down (0.5–1.5 lb/week is healthy). Prioritize protein (~1 g/lb lean mass) to protect muscle.
Weeks 4–8
Body composition visibly shifts. Add resistance training if you haven't — muscle preservation is the whole game.
Weeks 8+
Re-evaluate dose. Consider a maintenance drop or a scheduled break to reset receptor sensitivity.

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The reconstitution math

1Reconstitute the 10 mg vial with 2 mL of bacteriostatic water. Tilt — don't shake.
2Concentration becomes 5,000 mcg/mL (5 mg/mL).
3For a 500 mcg dose, draw 0.100 mL — that's 10 units on a 1 mL insulin syringe.
4One vial gives you approximately 20 doses.

Reminder: 100 units on an insulin syringe = 1 mL. Always start at half the listed dose for the first week and rotate injection sites between arms, legs, abdomen, and glutes.

Dose log

Dose logging is available for signed-in users. Track today's dose and notes for CagriSema Blend.