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Fat Loss

Tirzepatide dosing guide

A dual GIP and GLP-1 agonist with strong evidence for glucose control and substantial weight reduction.. Everything below is the arithmetic of this vial — what to mix, what to draw, how often, and for how long.

Also sold as: tirz, tirzep, mounjaro, zepbound, gip glp

The protocol at a glance

Vial size
10 mg
Bacteriostatic water
2 mL
Concentration
5.00 mg/mL
Dose
2 mg
Draw on a 1 mL syringe
40 units
Timing
AM
Frequency
1x per week
Cycle length
Until goal weight
Doses per vial
about 5

Suggested dose: 2mg once weekly; start at 1mg (1/2 dose) to test body reaction

Draw to here
00.0100.1200.2300.3400.4500.5600.6700.7800.8900.91001.0DRAW TO 40u100-UNIT · 1 mL SYRINGETirzepatide
Change the vial or water volume in the calculator →

Mixing it, step by step

Step by step

Reconstitution steps

Every step below uses the numbers you entered above.

  1. 1
    Wipe both stoppers

    Swab the rubber tops of the 10 mg Tirzepatide vial and the bacteriostatic water vial with fresh alcohol pads. Let them air dry for a few seconds.

  2. 2
    Draw 2 mL of BAC water

    Pull 2 mL of bacteriostatic water into a reconstitution syringe (usually a 3 mL syringe with a 21g needle).

  3. 3
    Add water slowly, down the side

    Inject the water against the inside wall of the vial, don't blast it directly onto the powder. This protects the peptide from shear damage.

  4. 4
    Swirl, don't shake

    Gently swirl until the powder is fully dissolved and the liquid is clear. Never shake, foaming denatures the peptide.

  5. 5
    Draw 40 units on a 1 mL syringe

    On your 100-unit (1 mL) insulin syringe, pull the plunger back until the rubber tip lines up with 40, that's your 2.00 mg dose. Tap out any air bubbles, then inject as directed.

  6. 6
    Store refrigerated

    Cap the vial and store at 2–8 °C (36–46 °F). Most reconstituted peptides remain stable for 3–4 weeks refrigerated.

What to expect, week by week

Week 1

Titrate up slowly. Expect appetite drop, mild nausea, and possible constipation with GLP-1s. Hydrate and lean on fiber.

Weeks 2–4

Steady weight trend down (0.5–1.5 lb/week is healthy). Prioritize protein (~1 g/lb lean mass) to protect muscle.

Weeks 4–8

Body composition visibly shifts. Add resistance training if you haven't — muscle preservation is the whole game.

Weeks 8+

Re-evaluate dose. Consider a maintenance drop or a scheduled break to reset receptor sensitivity.

Side effects to watch

  • Nausea, diarrhea, or constipation
  • Vomiting, reflux, or abdominal discomfort
  • Reduced appetite and dehydration
  • Gallbladder problems and injection-site reactions
  • Serious persistent abdominal pain needs urgent evaluation

Why people run it

  • Substantial A1C reduction in type 2 diabetes trials
  • Average weight reduction around 20% at higher studied doses in a major obesity trial
  • Improvements in waist circumference and several cardiometabolic markers
  • Once-weekly administration

What to stack it with

Ready to run Tirzepatide?

Read the full compound page, or check current pricing.

Educational reference only. Doses shown reflect commonly reported research protocols and are not medical advice.

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