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Fat Loss

Retatrutide dosing guide

The investigational triple agonist combining appetite control with an energy-expenditure signal.. Everything below is the arithmetic of this vial — what to mix, what to draw, how often, and for how long.

Also sold as: reta, retatru, retatrutid, triple agonist, lly-3437943

The protocol at a glance

Vial size
10 mg
Bacteriostatic water
2 mL
Concentration
5.00 mg/mL
Dose
2 mg
Draw on a 1 mL syringe
40 units
Timing
AM
Frequency
1x per week
Cycle length
Until goal weight
Doses per vial
about 5

Initial dose: 2mg once weekly (1/2 recommended starting dose)

Draw to here
00.0100.1200.2300.3400.4500.5600.6700.7800.8900.91001.0DRAW TO 40u100-UNIT · 1 mL SYRINGERetatrutide
Change the vial or water volume in the calculator →

Mixing it, step by step

Step by step

Reconstitution steps

Every step below uses the numbers you entered above.

  1. 1
    Wipe both stoppers

    Swab the rubber tops of the 10 mg Retatrutide vial and the bacteriostatic water vial with fresh alcohol pads. Let them air dry for a few seconds.

  2. 2
    Draw 2 mL of BAC water

    Pull 2 mL of bacteriostatic water into a reconstitution syringe (usually a 3 mL syringe with a 21g needle).

  3. 3
    Add water slowly, down the side

    Inject the water against the inside wall of the vial, don't blast it directly onto the powder. This protects the peptide from shear damage.

  4. 4
    Swirl, don't shake

    Gently swirl until the powder is fully dissolved and the liquid is clear. Never shake, foaming denatures the peptide.

  5. 5
    Draw 40 units on a 1 mL syringe

    On your 100-unit (1 mL) insulin syringe, pull the plunger back until the rubber tip lines up with 40, that's your 2.00 mg dose. Tap out any air bubbles, then inject as directed.

  6. 6
    Store refrigerated

    Cap the vial and store at 2–8 °C (36–46 °F). Most reconstituted peptides remain stable for 3–4 weeks refrigerated.

What to expect, week by week

Week 1

Titrate up slowly. Expect appetite drop, mild nausea, and possible constipation with GLP-1s. Hydrate and lean on fiber.

Weeks 2–4

Steady weight trend down (0.5–1.5 lb/week is healthy). Prioritize protein (~1 g/lb lean mass) to protect muscle.

Weeks 4–8

Body composition visibly shifts. Add resistance training if you haven't — muscle preservation is the whole game.

Weeks 8+

Re-evaluate dose. Consider a maintenance drop or a scheduled break to reset receptor sensitivity.

Side effects to watch

  • Nausea or vomiting
  • Diarrhea or constipation
  • Reduced appetite and fatigue
  • Increased heart rate
  • Potential class risks involving gallbladder, pancreas, dehydration, and severe GI symptoms

Why people run it

  • Mean weight reduction approached 24% at 48 weeks in the highest-dose Phase 2 group
  • Promising reductions in waist circumference and cardiometabolic risk markers
  • Research signal for reducing excess liver fat
  • Once-weekly pharmacology

What to stack it with

Ready to run Retatrutide?

Read the full compound page, or check current pricing.

Educational reference only. Doses shown reflect commonly reported research protocols and are not medical advice.

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